The PQBP1 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to PQBP1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The PQBP1 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species(PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit